This practical guide to setting up and managing a lab at a research intensive institution by Bob Goldstein and Prachee Avasthi explores key considerations for researchers transitioning into a principal investigator role. It has many practical suggestions, however, for those who already experienced at managing research groups. It highlights the early decisions that shape the trajectory of a research group, including negotiating resources, designing lab space, recruiting a team, and establishing effective ways of working. Many of these aspects of lab leadership are rarely taught formally, meaning new PIs often learn through experience. The guide helps make these hidden elements of running a lab more visible.

For Lab Builders, the resource highlights how decisions about infrastructure, hiring, and working practices can have long-term consequences for productivity and culture.

Key insights include:

• Planning lab space and infrastructure, considering collaboration, equipment needs, and future growth.
• Building peer networks with other new PIs, recognising the value of informal support and advice.
• Recruiting early team members strategically, as initial hires strongly influence lab culture and research momentum.

The central message is that building a research group requires both scientific vision and organisational leadership. Early attention to infrastructure, relationships, and culture helps create the conditions for a productive research environment.

“Recruitment and people management are central to success. Hire carefully and manage individuals, not generic roles.”

Benjamin Lichman, Senior Research Fellow / Senior Lecturer, University of York