Investigating Mitophagy Related Drug Mechanisms in Parkin Mutant Models.

This project aims to elucidate the mechanism by which mitophagy occurs in parkin mutant models with relation to Parkinson’s Disease. Parkinson’s is the second most common neurodegenerative disease and parkin mutations are the most common cause of early onset Parkinson’s. There is no disease modifying therapy in Parkinson’s. Mitophagy is the recycling of dysfunctional mitochondria and of paramount importance to neuronal populations.
Lead Academic at Lead Institution
Dr Heather Mortiboys – University of Sheffield
Lead Academics at Other Institutions
Dr Chris Elliott -University of York
Dr Ewan Morrison – University of Leeds
Other members of staff involved with this project
Dr Rachael Ivatt -University of Sheffield
Sangeeta Chawla – University of York
Dr Sandra Bell – University of Leeds

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